What does this research mean for the field?

Curative treatments for sickle cell disease generally present a weak value proposition to the healthcare system due to high incremental cost-effectiveness ratios, though their value proposition improves significantly when assessed from a societal perspective. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To summarize the methodologies and cost-effectiveness findings of published economic evaluations assessing curative therapies for sickle cell disease.

August 22, 2026Journal of sickle cell disease.Open Access

Systematic review of economic evaluations of curative treatments for sickle cell disease

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Authors

IAIjele AdimoraJohns Hopkins University BABethel AbrahamCenter for Global Health SJSanya JoshiWalsh University

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Implication

Systematic review reports high incremental cost-effectiveness ratios for curative sickle cell treatments, suggesting improved economic value when assessed from a societal perspective.

Key Points

To summarize the methodologies and cost-effectiveness findings of published economic evaluations assessing curative therapies for sickle cell disease.
Conducted a systematic review of published economic evaluations examining curative sickle cell disease interventions, including allogeneic hematopoietic stem cell transplantation and gene therapies.
Assessed modeling frameworks, cost data sources, health state utility values, analytical perspectives, time horizons, and incremental cost-effectiveness ratios.
Identified significant methodological heterogeneity across studies, with most reporting high incremental cost-effectiveness ratios exceeding accepted willingness-to-pay thresholds from a healthcare-payer perspective.
Observed that the cost-effectiveness and value proposition of curative therapies, particularly gene therapy, improved when evaluated using a broader societal perspective.
Found that most published models compared a single curative intervention against standard of care rather than directly comparing different curative modalities against each other.

Cite This Study

Adimora et al. (2026) studied this question.

synapsesocial.com/papers/6a895f53ca7ade938187dd1c https://doi.org/10.1093/jscdis/yoag038

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Implication

Systematic review reports high incremental cost-effectiveness ratios for curative sickle cell treatments, suggesting improved economic value when assessed from a societal perspective.

Systematic review of economic evaluations of curative treatments for sickle cell disease

Discussion

Member takes

Implication

Key Points

Cite This Study

Systematic review of economic evaluations of curative treatments for sickle cell disease

Discussion

Member takes

Implication

Key Points

Cite This Study

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