What does this research mean for the field?

A sequential locoregional treatment strategy combining transarterial radioembolization, chemoembolization, and external beam radiotherapy is feasible and can achieve complete radiologic response in highly selected patients with large hepatocellular carcinoma and macrovascular invasion. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the feasibility and efficacy of a sequential multimodal locoregional therapy combining radioembolization, chemoembolization, and external beam radiation for large hepatocellular carcinoma with vascular invasion.

August 22, 2026Journal of Digestive Cancer ResearchOpen Access

Complete Radiologic Response of the Treated Lesion Following Sequential Transarterial Radioembolization, Chemoembolization, and External Beam Radiotherapy in a Large Hepatocellular Carcinoma with Portal and Hepatic Vein Invasion: A Case Report

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Authors

JJJaehong JeongYonsei University DKDong Yun KimYonsei University

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Implication

Case report demonstrates complete radiologic response following sequential locoregional therapy in advanced hepatocellular carcinoma, suggesting viability for liver-confined vascular invasion.

Key Points

To evaluate the feasibility and efficacy of a sequential multimodal locoregional therapy combining radioembolization, chemoembolization, and external beam radiation for large hepatocellular carcinoma with vascular invasion.
Assessed a 68-year-old male with chronic hepatitis B and a 9.1-cm liver-confined hepatocellular carcinoma with right hepatic vein and posterior segmental portal vein tumor thrombi.
Delivered sequential transarterial radioembolization (TARE), consolidative conventional transarterial chemoembolization (cTACE), and external beam radiotherapy (EBRT) targeting the vascular thrombi.
Follow-up CT revealed no residual arterial enhancement in the target tumor, achieving a complete radiologic response according to modified RECIST criteria.
Serum PIVKA-II normalized, baseline liver function was maintained at Child-Pugh class A and ALBI grade 1, and no treatment-related adverse events were observed.

Cite This Study

Jeong et al. (2026) studied this question.

synapsesocial.com/papers/6a895f62ca7ade938187e004 https://doi.org/10.52927/jdcr.2026.14.2.169

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Implication

Case report demonstrates complete radiologic response following sequential locoregional therapy in advanced hepatocellular carcinoma, suggesting viability for liver-confined vascular invasion.

Complete Radiologic Response of the Treated Lesion Following Sequential Transarterial Radioembolization, Chemoembolization, and External Beam Radiotherapy in a Large Hepatocellular Carcinoma with Portal and Hepatic Vein Invasion: A Case Report

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Cite This Study

Complete Radiologic Response of the Treated Lesion Following Sequential Transarterial Radioembolization, Chemoembolization, and External Beam Radiotherapy in a Large Hepatocellular Carcinoma with Portal and Hepatic Vein Invasion: A Case Report

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