May 1, 1977Journal of Cellular Physiology

The binding sites of cytochalasin D. I. Evidence that they may be peripheral membrane proteins

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Population

Isolated plasma membrane from HEp-2 cells

Design

Preclinical

Authors

JTJanet TannenbaumColumbia University STStuart W. TanenbaumState University of New York GGGabriel C. GodmanRockefeller Foundation

Discussion

Member takes

Implication

No immediate clinical implications; leaves open whether these sites modulate cardiac contractility in vivo.

Structured PICO

Population

Isolated plasma membrane from HEp-2 cells

Intervention

Tritiated cytochalasin D (3H-CD) binding, dialysis in 0.6 M KCl, treatment with 0.2 mM ATP, extraction with 6% Triton X-100

Outcome

Binding activity of 3H-CDsurrogate

Plasma membrane binding sites for cytochalasin D appear to be peripheral proteins on the cytoplasmic face, potentially involving myosin and actomyosin.

Cite This Study

Tannenbaum et al. (1977) studied this question.

synapsesocial.com/papers/6a895f6a1e528df4f2ec6376 https://doi.org/10.1002/jcp.1040910208

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Bookmark

The binding sites of cytochalasin D. I. Evidence that they may be peripheral membrane proteins

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The binding sites of cytochalasin D. I. Evidence that they may be peripheral membrane proteins

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider