Recurrent giant cell tumor of the distal radius managed with surgical strategies aimed at preserving function

Giant cell tumor (GCTB) of bone is a benign yet locally aggressive neoplasm typically affecting the epiphysis of long bones in young adults. GCTBs of the distal radius are rare and pose significant therapeutic challenges due to their proximity to the wrist joint and tendency for recurrence. This case report describes the management of a 46-year-old Saudi male with recurrent GCTB of the distal radius over a five-year period. He initially presented with wrist pain and was diagnosed radiologically and histologically with GCTB with secondary aneurysmal bone cyst changes. Despite multiple surgical interventions, including curettage, cementation, plating, wrist fusion, and flap coverage, the tumor recurred three times. He also received denosumab therapy, which induced partial response. The patient ultimately declined additional reconstructive surgery, maintained good hand function, and had no recurrences at the last follow-up. This case emphasizes the value of multidisciplinary management, tailored treatment, and long-term follow-up in recurrent distal radius GCTB.