Preclinical study demonstrates xenoreduced generation of functional oral keratinocytes from human adult fibroblast-derived iPSCs, suggesting viable strategies for oral mucosal regeneration.
This study investigated xenoreduced generation of oral keratinocytes from induced pluripotent stem cells (iPSCs) derived from adult oral and skin fibroblasts for oral mucosal regeneration. Using an extracellular matrix-based protocol, iPSCs were differentiated into cells with a phenotype and molecular profile of oral epithelium, in both serum-containing and xenoreduced conditions. In vivo tests validated the viability of multilayered squamous epithelial-like tissues formed by cells derived from gingival fibroblast iPSCs.
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Das et al. (2026) studied this question.
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