Validation of an integrated analytical method for the simultaneous quantification of 12 PFAS in drinking water, plant-based milk alternatives and skimmed milk
Method validation study demonstrates sensitive quantification of 12 PFAS in water, plant-based milk, and skimmed milk, highlighting a robust approach for routine food safety monitoring.
Key Points
Validate an integrated analytical workflow for the simultaneous quantification of 12 per- and polyfluoroalkyl substances (PFAS) in drinking water, plant-based milk alternatives, and skimmed milk.
Extracted food samples using QuEChERS followed by a unified one-step solid-phase extraction cleanup across all matrices.
Quantified 12 PFAS using ultra-high-performance liquid chromatography-tandem mass spectrometry with isotope dilution to correct for matrix effects.
Achieved linearity (R² ≥ 0.990) with limits of quantification of 0.0005 μg/L for water and 0.0040 μg/kg for food matrices, with relative standard deviations < 20%.
Demonstrated PFAS concentrations below the limit of quantification in nearly all tested commercial samples.