What does this research mean for the field?

Higher pesticide exposures, specifically to chlorpyrifos and oxyfluorfen, measured via silicone wristbands are associated with lower kidney function in agricultural workers. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.ESTABLISHES_NEW_DIRECTION.

What question did this study set out to answer?

To evaluate the feasibility of silicone wristbands for assessing personal chemical exposome profiles and their associations with kidney function and urinary biomarkers among agricultural workers.

August 22, 2026Environmental Health PerspectivesOpen Access

A Pilot Study to Explore the Application of Silicone Wristband-Based Chemical Exposure Assessment to Kidney Disease Epidemiology in Agricultural Workers

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Authors

MDMelissa Desantiago GTGrant D. Tore NHNicholas J. Herkert

Discussion

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Overview

Pilot study finds wristband pesticide exposure links to reduced kidney function in agricultural workers, indicating wearable samplers enhance biomonitoring.

Key Points

To evaluate the feasibility of silicone wristbands for assessing personal chemical exposome profiles and their associations with kidney function and urinary biomarkers among agricultural workers.
Assessed 43 male agricultural workers wearing silicone wristbands for 8–11 days alongside spot urine sample collection.
Quantified pesticide exposures using targeted analysis and high-resolution gas chromatography mass spectrometry (GC-HRMS) nontargeted screening.
Evaluated associations with estimated glomerular filtration rate (eGFR) and binary reduced kidney function (eGFR < 90 mL/min/1.73m2) using linear and log-binomial regression.
A 10-fold increase in wristband chlorpyrifos was associated with higher prevalence of eGFR < 90 mL/min/1.73m2 (PR = 1.53; 95% CI: 0.99, 2.36), and oxyfluorfen detection was similarly associated with reduced eGFR (PR = 2.38; 95% CI: 1.01, 5.61).
Most urinary biomarkers showed no association with eGFR, although specific gravity-corrected urinary aminomethylphosphonic acid (AMPA) was inversely associated with eGFR < 90 mL/min/1.73m2 (PR = 0.31; 95% CI: 0.11, 0.87).
Nontargeted screening identified 193 tentative chemical features elevated on wristbands worn by participants with eGFR < 90 mL/min/1.73m2 compared to only one feature elevated in participants with eGFR ≥ 90 mL/min/1.73m2.

Cite This Study

Desantiago et al. (2026) studied this question.

synapsesocial.com/papers/6a895facca7ade938187e6ea https://doi.org/10.1021/ehp.6c00319

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August 22, 2026Environmental Health PerspectivesOpen Access

A Pilot Study to Explore the Application of Silicone Wristband-Based Chemical Exposure Assessment to Kidney Disease Epidemiology in Agricultural Workers

View Full Paper

Ask AI

Bookmark

Authors

MDMelissa Desantiago GTGrant D. Tore NHNicholas J. Herkert

Discussion

Member takes

Overview

Pilot study finds wristband pesticide exposure links to reduced kidney function in agricultural workers, indicating wearable samplers enhance biomonitoring.

Key Points

To evaluate the feasibility of silicone wristbands for assessing personal chemical exposome profiles and their associations with kidney function and urinary biomarkers among agricultural workers.
Assessed 43 male agricultural workers wearing silicone wristbands for 8–11 days alongside spot urine sample collection.
Quantified pesticide exposures using targeted analysis and high-resolution gas chromatography mass spectrometry (GC-HRMS) nontargeted screening.
Evaluated associations with estimated glomerular filtration rate (eGFR) and binary reduced kidney function (eGFR < 90 mL/min/1.73m2) using linear and log-binomial regression.
A 10-fold increase in wristband chlorpyrifos was associated with higher prevalence of eGFR < 90 mL/min/1.73m2 (PR = 1.53; 95% CI: 0.99, 2.36), and oxyfluorfen detection was similarly associated with reduced eGFR (PR = 2.38; 95% CI: 1.01, 5.61).
Most urinary biomarkers showed no association with eGFR, although specific gravity-corrected urinary aminomethylphosphonic acid (AMPA) was inversely associated with eGFR < 90 mL/min/1.73m2 (PR = 0.31; 95% CI: 0.11, 0.87).
Nontargeted screening identified 193 tentative chemical features elevated on wristbands worn by participants with eGFR < 90 mL/min/1.73m2 compared to only one feature elevated in participants with eGFR ≥ 90 mL/min/1.73m2.

Cite This Study

Desantiago et al. (2026) studied this question.

synapsesocial.com/papers/6a895facca7ade938187e6ea https://doi.org/10.1021/ehp.6c00319

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