Why the study?
Patients with HIV are at increased cardiovascular risk, but little is known regarding ischemic stroke risk in HIV-infected individuals with AF.
Does HIV infection increase the risk of ischemic stroke/SE and major bleeding in patients with atrial fibrillation?
Does HIV infection increase the risk of ischemic stroke/SE and major bleeding in patients with atrial fibrillation?
HIV-infected patients with AF have a significantly higher risk of ischemic stroke and major bleeding compared to non-HIV patients, yet oral anticoagulant use remains suboptimal.
BACKGROUND: Patients infected with human immunodeficiency virus (HIV) are at increased risk of cardiovascular diseases. However, little is known regarding the risk of ischemic stroke in HIV-infected individuals with atrial fibrillation (AF). METHODS AND RESULTS: -VASc score of 1) (2.04 vs. 2.18 events per 100 person-years). However, the use of OACs in AF patients with HIV was suboptimal, being only 8.9% at the time of AF diagnosis and 31.8% throughout the study period. CONCLUSIONS: The risks of ischemic stroke/SE and major bleeding were significantly higher in HIV-infected patients compared with non-HIV-infected patients with AF. Despite this, the actual use of OACs among AF patients with HIV was suboptimal.
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Jung et al. (2019) studied this question.
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