What does this research mean for the field?

Preoperative platelet function testing and postoperative viscoelastic testing have limited discriminatory performance and are not independently associated with postoperative bleeding in CABG surgery after multivariable adjustment, indicating they should not be used as standalone predictive models. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the clinical significance of preoperative platelet function testing and postoperative viscoelastic testing for predicting bleeding and transfusion in patients undergoing on-pump coronary artery bypass grafting.

August 22, 2026Journal of Clinical MedicineOpen Access

Evaluating the Clinical Significance of Pre- and Postoperative Platelet Function Testing in Coronary Artery Bypass Grafting Surgery

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Authors

MMMiloš MatkovićUniversity of Belgrade TNTina NovakovicUniversity of Belgrade AMAleksandar MilojevićUniversity of Belgrade

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Implication

Prospective observational study reveals perioperative platelet function tests lack independent predictive value for bleeding in bypass surgery, indicating they cannot serve as standalone tools.

Key Points

To evaluate the clinical significance of preoperative platelet function testing and postoperative viscoelastic testing for predicting bleeding and transfusion in patients undergoing on-pump coronary artery bypass grafting.
Prospective observational study of 708 patients undergoing elective isolated on-pump coronary artery bypass grafting between January 2023 and January 2025.
Preoperative platelet function was measured using Multiplate impedance aggregometry (ADPHS and ASPI) and postoperative coagulation was evaluated with ClotPro viscoelastic testing after cardiopulmonary bypass.
Postoperative bleeding was assessed via cumulative chest-tube drainage during the first 24 hours.
In unadjusted analyses, low ADPHS demonstrated modest discrimination for blood loss > 500 mL/24 h (AUC = 0.61, p = 0.041) and low ASPI showed modest discrimination for blood loss > 1000 mL/24 h (AUC = 0.62, p = 0.005).
Following multivariable adjustment, neither ADPHS ≤ 602.5 AU·min (adjusted OR 1.01, 95% CI 0.74–1.39, p = 0.936) nor ASPI ≤ 453 AU·min (adjusted OR 0.89, 95% CI 0.64–1.23, p = 0.475) remained independently associated with postoperative bleeding > 500 mL/24 h.
Postoperative ClotPro viscoelastic parameters correlated significantly with transfusion and bleeding endpoints, but their overall discriminatory performance was limited.

Cite This Study

Matković et al. (2026) studied this question.

synapsesocial.com/papers/6a895fd3ca7ade938187eab8 https://doi.org/10.3390/jcm15166440

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Implication

Prospective observational study reveals perioperative platelet function tests lack independent predictive value for bleeding in bypass surgery, indicating they cannot serve as standalone tools.

Evaluating the Clinical Significance of Pre- and Postoperative Platelet Function Testing in Coronary Artery Bypass Grafting Surgery

Discussion

Member takes

Implication

Key Points

Cite This Study

Evaluating the Clinical Significance of Pre- and Postoperative Platelet Function Testing in Coronary Artery Bypass Grafting Surgery

Discussion

Member takes

Implication

Key Points

Cite This Study

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