What does this research mean for the field?

Mortality involving both pancreatic cancer and pulmonary embolism has increased substantially in the United States from 1999 to 2024, with pulmonary embolism being recorded in a growing proportion of pancreatic cancer deaths. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate longitudinal trends and demographic disparities in mortality involving both pancreatic cancer and pulmonary embolism among adults in the United States from 1999 to 2024.

August 22, 2026DiseasesOpen Access

Trends and Disparities in Mortality Involving Pancreatic Cancer and Pulmonary Embolism in the United States, 1999–2024: A CDC WONDER Analysis

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Authors

ADArkadeep DhaliQueen's University Belfast JBJyotirmoy BiswasGovernment Medical College AHAli Shan HafeezNishtar Medical College and Hospital

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Implication

Epidemiological study reveals rising mortality from pulmonary embolism in pancreatic cancer patients, highlighting an increasing population-level clinical burden.

Key Points

To evaluate longitudinal trends and demographic disparities in mortality involving both pancreatic cancer and pulmonary embolism among adults in the United States from 1999 to 2024.
Analyzed CDC WONDER Multiple Cause of Death records for adults aged ≥25 years (N=18,243 deaths) with co-occurring pancreatic cancer and pulmonary embolism.
Calculated age-adjusted mortality rates (AAMRs) using Joinpoint regression, weighted log-linear, and segmented regression models, including a sensitivity analysis excluding the COVID-19 pandemic period (2020–2021).
Overall AAMR increased from 0.19 per 100,000 in 1999 to 0.55 per 100,000 in 2024, with annual increases accelerating from 2.65% (1999–2016) to 8.54% (2016–2024; p < 0.001).
The proportion of pancreatic cancer underlying-cause deaths with pulmonary embolism recorded increased from 1.00% in 1999 to 2.85% in 2024 (post-2016 acceleration p < 0.001), with consistently higher rates in males and non-Hispanic Black individuals.

Cite This Study

Dhali et al. (2026) studied this question.

synapsesocial.com/papers/6a895fd3ca7ade938187ec87 https://doi.org/10.3390/diseases14080303

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Implication

Epidemiological study reveals rising mortality from pulmonary embolism in pancreatic cancer patients, highlighting an increasing population-level clinical burden.

Trends and Disparities in Mortality Involving Pancreatic Cancer and Pulmonary Embolism in the United States, 1999–2024: A CDC WONDER Analysis

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Implication

Key Points

Cite This Study

Trends and Disparities in Mortality Involving Pancreatic Cancer and Pulmonary Embolism in the United States, 1999–2024: A CDC WONDER Analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

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