What does this research mean for the field?

A thiocarbonyl-directed rhodium-catalyzed C2-selective C─H bond activation and cyclization of N,N-dimethylthioamide indoles with alkynes efficiently produces substituted pyrrolo[1,2-a]indole-3-thiones under redox-neutral conditions. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To establish an efficient, thiocarbonyl-directed rhodium-catalyzed strategy for C2-selective C–H functionalization and cyclization of N,N-dimethylthioamide indoles with alkynes.

August 22, 2026Advanced Synthesis & Catalysis

Thiocarbonyl‐Directed Rhodium‐Catalyzed C2‐Selective C─H Bond Activation and Cyclization of N , N ‐Dimethylthioamide Indoles With Alkynes

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Authors

YSYuhang SunShandong Academy of Agricultural Sciences JWJiangwei WenQufu Normal University QLQiuyun LiYancheng Institute of Technology

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Implication

Chemical synthesis study demonstrates rhodium-catalyzed C2-selective C–H cyclization of thioamide indoles with alkynes, indicating an efficient redox-neutral route to pyrrolo[1,2-a]indole-3-thiones.

Key Points

To establish an efficient, thiocarbonyl-directed rhodium-catalyzed strategy for C2-selective C–H functionalization and cyclization of N,N-dimethylthioamide indoles with alkynes.
Coupled stable N,N-dimethylthioamide indoles with alkynes using a rhodium catalytic system.
Conducted the cyclization reactions under redox-neutral reaction conditions.
Explored synthetic potential and conducted preliminary mechanistic investigations.
Efficiently generated a broad library of substituted pyrrolo[1,2-a]indole-3-thione derivatives.
Maintained precise C2-selectivity for indole functionalization while fully retaining the thiocarbonyl group.

Cite This Study

Sun et al. (2026) studied this question.

synapsesocial.com/papers/6a895fe4ca7ade938187ed2e https://doi.org/10.1002/adsc.70730

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Thiocarbonyl‐Directed Rhodium‐Catalyzed C2‐Selective C─H Bond Activation and Cyclization of N , N ‐Dimethylthioamide Indoles With Alkynes

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Key Points

Cite This Study

Thiocarbonyl‐Directed Rhodium‐Catalyzed C2‐Selective C─H Bond Activation and Cyclization of N , N ‐Dimethylthioamide Indoles With Alkynes

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Cite This Study

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