Resurgence of Malaria in Ethiopia

Q: What does this research mean for the field?

Emerging drug and diagnostic resistance variants are potential drivers of the recent malaria resurgence in Ethiopia. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Ashenafi Assefa; Bokretsion G. Brhane; Isabela Gerdes Gyuricza; Heven Sime; Mahlet Belachew; Mesay Hailu Dangisso; Getachew Tollera; Jeffrey A. Bailey; Jonathan J. Juliano; Abebe A. Fola (9543709); Geremew Tasew; Jonathan B. Parr; Malaria Resurgence Investigation Group; Adugna Abera; Sisay Adane; Gebrie Alebachew; Abraham Ali; Zahara Ayalew; Mulu Berihun; Dinkenesh Chalchisa; Abeba Geberetsadik; Atsbeha G. Weldemariam; Melak Getu; Christopher M. Hennelly; Michael T. Ferdig; Hiwot Solomon; Rajiha A. Ibrahim; Enirsie Kassie; Oksana Kharabora; Jacob M. Sadler; Alfred Simkin; Gemechu Tadesse; Addisu Tesfaye; Mahelet Tesfaye; Kyaw L Thwai; Yonas Weletaw; Girma Zerefaw

doi:10.1001/jama.2026.14688

Key result

Emerging drug and diagnostic resistance variants are linked to malaria resurgence in Ethiopia.

Key Points

To evaluate whether emerging drug-resistant and diagnostic-resistant parasite strains are driving the resurgence of malaria cases in Ethiopia.
Assessed surveillance data and parasite genetic profiles to detect markers of diagnostic escape and antimalarial drug resistance.
Identified diagnostic escape mutations capable of circumventing detection by conventional rapid diagnostic tests.
Detected antimalarial resistance mutations associated with reduced therapeutic efficacy and increased transmission.

Structured PICO

P

Population

Populations in Ethiopia affected by malaria

This study investigates the role of emerging drug and diagnostic resistance variants in the resurgence of malaria in Ethiopia.

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Implication

May warrant updated malaria surveillance in Ethiopia; hypothesis-generating for resistance as resurgence driver pending prospective studies.

Abstract

This study examines whether emerging drug and diagnostic resistance variants are contributing to Ethiopia’s malaria resurgence.

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Cite This Study

Assefa et al. (2026) studied this question. Emerging drug and diagnostic resistance variants are being investigated as potential contributors to the resurgence of malaria in Ethiopia.

synapsesocial.com/papers/6a895fe4ca7ade938187edb1 https://doi.org/10.1001/jama.2026.14688

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Resurgence of Malaria in Ethiopia

Key Points

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Resurgence of Malaria in Ethiopia

Key Points

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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