What does this research mean for the field?

A novel 1,2,3-triazole-sulfonamide conjugate featuring a 2,5-dichlorophenyl moiety (compound 7h) exhibits broad-spectrum antimicrobial and antiparasitic activity, with chloro-substitution on the sulfonamide ring being critical for enhanced biological efficacy. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To rationally design, synthesize, and evaluate the antimicrobial and antiparasitic properties of a series of novel 1,2,3-triazole-sulfonamide hybrid molecules.

August 22, 2026Discover Chemistry.Open Access

Design, synthesis, and biological evaluation of novel sulfonamide-linked 1,2,3-triazole conjugates

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Authors

DPDineshkumar PagarSwami Ramanand Teerth Marathwada University RSRanjay ShawGLA University DRDhanji RajaniMemorialCare Health System

Discussion

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Implication

In vitro experimental study demonstrates broad antimicrobial and antiparasitic activity of novel triazole-sulfonamide conjugates, highlighting their potential as therapeutic lead structures.

Key Points

To rationally design, synthesize, and evaluate the antimicrobial and antiparasitic properties of a series of novel 1,2,3-triazole-sulfonamide hybrid molecules.
Synthesized eight 1,2,3-triazole-sulfonamide conjugates (7a–h) using copper(I)-catalysed azide-alkyne cycloaddition (CuAAC).
Characterized all synthetic conjugates and evaluated in vitro activity against Escherichia coli, Candida albicans, Plasmodium falciparum, and Mycobacterium tuberculosis.
Compound 7h (bearing a 2,5-dichlorophenyl moiety) exhibited the strongest activity, yielding an IC₅₀ of 0.62 µg/mL against P. falciparum, and MICs of 50 µg/mL against E. coli, 50 µg/mL against M. tuberculosis, and 250 µg/mL against C. albicans.
Structure-activity relationship (SAR) analysis showed that chloro-substitution on the sulfonamide ring significantly improves antimicrobial and antiparasitic efficacy.

Cite This Study

Pagar et al. (2026) studied this question.

synapsesocial.com/papers/6a895fe4ca7ade938187edd3 https://doi.org/10.1007/s44371-026-00907-y

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Implication

In vitro experimental study demonstrates broad antimicrobial and antiparasitic activity of novel triazole-sulfonamide conjugates, highlighting their potential as therapeutic lead structures.

Design, synthesis, and biological evaluation of novel sulfonamide-linked 1,2,3-triazole conjugates

Discussion

Member takes

Implication

Key Points

Cite This Study

Design, synthesis, and biological evaluation of novel sulfonamide-linked 1,2,3-triazole conjugates

Discussion

Member takes

Implication

Key Points

Cite This Study

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