What does this research mean for the field?

Deficiencies or disruptions in specific complement proteins lead to distinct clinical manifestations, including increased susceptibility to infections, autoimmunity, and thrombosis, which require targeted diagnostic and management strategies. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

Review the pathophysiology, clinical manifestations, diagnostic protocols, and management strategies for complement protein deficiencies.

August 22, 2026Journal of Human ImmunityOpen Access

Complement Disorders and Inborn Errors of Immunity

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Authors

GPGordana PetrovićInstitute of Public Health of Serbia

Discussion

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Implication

Review outlines clinical manifestations and diagnostic pathways across complement deficiencies, highlighting targeted vaccination and antibiotic prophylaxis.

Key Points

Review the pathophysiology, clinical manifestations, diagnostic protocols, and management strategies for complement protein deficiencies.
Synthesized clinical literature detailing genetic disruptions across classical, alternative, and lectin complement pathways.
Evaluated functional diagnostic screening assays (CH50, AH50, ELISA) and specific immunoassay factor quantification.
Classical pathway defects (C1q, C1r, C1s, C2, C4) frequently present as autoimmune conditions like systemic lupus erythematosus, while terminal pathway deficiencies (C5–C9) predispose to invasive Neisseria meningitidis infections.
Central C3 deficiency leads to recurrent severe infections and glomerulonephritis, whereas regulatory factor H and I deficiencies are associated with hemolytic-uremic syndrome.
Effective clinical management combines functional screening assays with individualized preventive strategies, including vaccination against encapsulated bacteria and prophylactic antibiotics.

Cite This Study

Gordana Petrović (2026) studied this question.

synapsesocial.com/papers/6a89600eca7ade938187f26d https://doi.org/10.70962/sgpi2026abstract.6

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Implication

Review outlines clinical manifestations and diagnostic pathways across complement deficiencies, highlighting targeted vaccination and antibiotic prophylaxis.

Complement Disorders and Inborn Errors of Immunity

Discussion

Member takes

Implication

Key Points

Cite This Study

Complement Disorders and Inborn Errors of Immunity

Discussion

Member takes

Implication

Key Points

Cite This Study

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