Why the study?
Does coronary revascularization affect intrinsic plasma volume deficits in patients with coronary artery obstruction and disabling angina?
Does coronary revascularization affect intrinsic plasma volume deficits in patients with coronary artery obstruction and disabling angina?
Patients with coronary artery disease and disabling angina may have significant intrinsic plasma volume deficits (oligemia) that persist months after successful revascularization.
Persistent oligemia may remain after revascularization despite symptom relief; hypothesis-generating and should not yet change practice.
Plasma volumes, red blood cell volumes, large vessel hematocrit readings, and total blood volumes were measured before operation, immediately after operation, and four to six months later in 12 patients with coronary artery obstruction, disabling angina, and normal left ventricular function. There were significant plasma volume deficits in all patients before and six months after operation despite complete amelioration of angina and replenishment of the plasma volume immediately after surgery. The importance of recognizing possibly significant preoperative oligemia in patients undergoing coronary revascularization is emphasized.
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Lawrence H. Cohn (1974) studied this question.
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