Why the study?
Does reduced adrenergic function via guanethidine or phenoxybenzamine affect plasma volume in normal subjects?
Population
10 normal subjects
Design
Other
Follow-up
3 weeks
Authors
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Hypothesis-generating for sympathetic control of plasma volume; leaves open relevance to patients or outcomes.
Does reduced adrenergic function via guanethidine or phenoxybenzamine affect plasma volume in normal subjects?
Interference with adrenergic function using guanethidine or phenoxybenzamine increases plasma volume and forearm venous compliance in normal subjects, suggesting sympathetic control of venous resistance regulates blood volume.
Weil et al. (1968) studied this question.
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