Why the study?
Does guanadrel-induced suppression of sympathetic nervous system activity upregulate arterial alpha-adrenergic responsiveness in humans?
Population
10 human subjects, age 19-28 years
Comparison
Guanadrel vs Placebo
Design
Other
Authors
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Supports homologous alpha-adrenergic upregulation after sympathetic suppression; hypothesis-generating and should not change practice.
Does guanadrel-induced suppression of sympathetic nervous system activity upregulate arterial alpha-adrenergic responsiveness in humans?
Suppression of sympathetic nervous system activity by guanadrel leads to homologous upregulation of arterial alpha-adrenergic responsiveness to norepinephrine in humans.
Hogikyan et al. (1993) studied this question.
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