Why the study?
Does the addition of guanadrel to diuretic therapy alter in vitro and in vivo measures of adrenergic function in patients with essential hypertension?
Population
11 patients with essential hypertension on diuretic therapy
Comparison
Addition of guanadrel to diuretic therapy vs Baseline (pre-treatment)
Design
Cohort
Authors
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Guanadrel was associated with BP reduction and platelet alpha-2 upregulation without in vivo response changes; leaves open their clinical relevance in hypertension.
Does the addition of guanadrel to diuretic therapy alter in vitro and in vivo measures of adrenergic function in patients with essential hypertension?
Pharmacologic reduction of sympathetic drive with guanadrel increases in vitro platelet alpha-2 receptor numbers without altering in vivo physiologic responses to alpha-agonists, highlighting the limitations of extrapolating in vitro findings to in vivo significance.
Egan et al. (1985) studied this question.