Key result
Blood pressure disturbances altered platelet alpha 2-adrenoceptor density, which increased in Parkinsonians with orthostatic hypotension and decreased in essential hypertension (both p<0.05).
Why the study?
Do blood pressure disturbances affect platelet alpha 2-adrenoceptor density?
Population
7 normotensive Parkinsonians with orthostatic hypotension, 23 mild essential hypertensive patients, and age…
Design
Case-control
Authors
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Platelet alpha 2-adrenoceptor density changes should not yet guide therapy; leaves open mechanistic and prognostic roles in hypertension and orthostatic hypotension.
Observational
Do blood pressure disturbances affect platelet alpha 2-adrenoceptor density?
Absolute Event Rate: 313% vs 174%
p-value: p=< 0.05
Platelet alpha 2-adrenoceptor density is related to blood pressure values, showing up-regulation in orthostatic hypotension due to decreased catecholamines and down-regulation in essential hypertension.
Galinier et al. (1994) conducted an observational in Orthostatic hypotension in Parkinson's disease and essential hypertension. Blood pressure disturbances (orthostatic hypotension and essential hypertension) vs. Normotensive controls was evaluated on Platelet alpha 2-adrenoceptor number (fmol/mg protein) (p=< 0.05). Blood pressure disturbances altered platelet alpha 2-adrenoceptor density, which increased in Parkinsonians with orthostatic hypotension and decreased in essential hypertension (both p<0.05).
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