Key result
Plasma noradrenaline concentration correlates with blood pressure and alpha-adrenoreceptor-mediated vasoconstriction in patients with essential hypertension, but not in normotensive subjects.
Why the study?
Does plasma noradrenaline correlate with alpha-adrenoreceptor-mediated vasoconstriction and blood pressure in patients with essential hypertension?
Population
44 hypertensive patients and 14 normotensive subjects of similar age
Comparison
Brachial artery infusion of the… vs Normotensive subjects
Design
Cross-sectional
Authors
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May support noradrenaline as vasoconstriction marker in essential hypertension; leaves open causal role and need for prospective trials.
Cross-Sectional (n=58)
Does plasma noradrenaline correlate with alpha-adrenoreceptor-mediated vasoconstriction and blood pressure in patients with essential hypertension?
In patients with essential hypertension, plasma noradrenaline serves as a marker of alpha-adrenoreceptor-mediated vasoconstriction, which partially determines blood pressure.
Kiowski et al. (1979) conducted a cross-sectional in Essential Hypertension (n=58). Plasma noradrenaline concentration vs. Normotensive subjects was evaluated on Correlation between plasma noradrenaline and blood pressure, and forearm blood flow response to phentolamine. Plasma noradrenaline concentration correlates with blood pressure and alpha-adrenoreceptor-mediated vasoconstriction in patients with essential hypertension, but not in normotensive subjects.