Key result
Plasma noradrenaline concentration was elevated in essential hypertension but 28 times greater in phaeochromocytoma, suggesting excess sympathetic drive only partly explains blood pressure levels.
Population
Patients with established essential hypertension, along with unspecified numbers of patients with endogenous…
Design
Cross-sectional
Authors
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Supports partial sympathetic role in essential hypertension; leaves open other mechanisms and requires prospective validation.
Observational
Excess sympathetic drive, as measured by plasma noradrenaline, only partially explains the elevation of blood pressure in essential hypertension.
Louis et al. (1974) conducted an observational in Essential hypertension, phaeochromocytoma, and depression. Plasma noradrenaline concentration vs. Endogenous depression and phaeochromocytoma was evaluated on Blood pressure. Plasma noradrenaline concentration was elevated in essential hypertension but 28 times greater in phaeochromocytoma, suggesting excess sympathetic drive only partly explains blood pressure levels.
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