Why the study?
Does sympathetic activity correlate with blood pressure levels in patients with essential hypertension?
Observational (n=31)
Does sympathetic activity correlate with blood pressure levels in patients with essential hypertension?
The level of blood pressure in essential hypertension is at least in part due to excess sympathetic activity, as evidenced by the correlation between blood pressure and plasma noradrenaline levels before and after ganglionic blockade.
Correlations support sympathetic overactivity in essential hypertension; leaves open whether targeted blockade improves outcomes.
In thirty-one patients with essential hypertension there was a close relationship between resting diastolic blood pressure and basal plasma noradrenaline levels (r = 0.729, P 2. After ganglionic blockade there was a highly significant correlation between change in resting blood pressure and change in plasma noradrenaline (r = 0.813, P<0*001). 3. Patients with the highest resting blood pressure had the largest falls in blood pressure and plasma noradrenaline. 4. These results suggest that the level of the blood pressure in essential hypertension is at least in part due to excess of sympathetic activity.
No takes yet. Share an insight, caveat, or question.
Louis et al. (1973) conducted an observational in Essential hypertension (n=31). Sympathetic activity (plasma noradrenaline levels) was evaluated on Correlation between resting diastolic blood pressure and basal plasma noradrenaline levels (r = 0.729).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: