December 6, 2001Clinical and Experimental Pharmacology and Physiology
Sympathetic Nerve Biology In Essential Hypertension
Key result
Sympathetic nervous dysfunction in essential hypertension involves increased noradrenaline spillover, adrenaline cotransmission, and faulty noradrenaline reuptake in cardiac sympathetic nerves.
Population
Patients with essential hypertension and spontaneously hypertensive rats
Design
Review
Authors
Discussion
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Implication
No immediate change to hypertension management; leaves open whether targeting sympathetic mechanisms improves outcomes.
Structured PICO
P
Population
Patients with essential hypertension and spontaneously hypertensive rats
This review highlights potential pathophysiological mechanisms underlying sympathetic nervous activation in essential hypertension, including altered neurotransmitter reuptake and cotransmission.
Cite This Study
Esler et al. (2001) conducted a review in Essential hypertension. Sympathetic nervous activation was evaluated. Sympathetic nervous dysfunction in essential hypertension involves increased noradrenaline spillover, adrenaline cotransmission, and faulty noradrenaline reuptake in cardiac sympathetic nerves.