February 28, 2003Acta Physiologica Scandinavica
Sympathetic nerve activity and neurotransmitter release in humans: translation from pathophysiology into clinical practice
Key result
Sympathetic nerve activity is markedly increased in cardiovascular diseases, with renal noradrenaline spillover doubling in obesity and cardiac spillover increasing up to 50-fold in heart failure.
Design
Review
Authors
Discussion
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Member takes
Implication
Supports sympathetic inhibition strategies in heart failure and obesity hypertension; leaves open optimal patient selection for neuromodulation.
PICO
P
Population
Obesity-related hypertension, essential hypertension, and cardiac failure
E
Exposure / Comparator
Sympathetic nervous system activation
This review highlights the translation of cardiovascular neuroscience into clinical practice, demonstrating how increased sympathetic nerve activity underpins obesity-related hypertension, essential hypertension, and heart failure.
Cite This Study
Esler et al. (2003) conducted a review in Obesity-related hypertension, essential hypertension, and cardiac failure. Sympathetic nervous system activation was evaluated. Sympathetic nerve activity is markedly increased in cardiovascular diseases, with renal noradrenaline spillover doubling in obesity and cardiac spillover increasing up to 50-fold in heart failure.