What does this research mean for the field?

Patients with mild essential hypertension exhibit increased plasma catecholamines compared to matched controls following upright tilt or cold pressor testing, reflecting abnormal peripheral sympathetic activity in specific hypertensive subgroups. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate peripheral sympathetic nervous system activity in essential hypertension by measuring plasma catecholamines and norepinephrine under basal and stimulated conditions.

September 1, 1978Journal of Human Stress

Studies on the Activity of the Sympathetic Nervous System in Essential Hypertension

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Essential hypertension. Intervention: Mild essential hypertension vs. Matched controls. Primary outcome: Plasma catecholamine and norepinephrine concentrations.

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Key result

Mild essential hypertension linked to higher plasma catecholamines after upright tilt or cold pressor testing.

Why the study?

Are plasma catecholamine and norepinephrine concentrations altered in patients with essential hypertension under basal and stimulated conditions?

Population

Ambulatory patients with essential hypertension and matched controls

Comparison

Experimental procedures to enhance sympathetic… vs Matched controls

Design

Cross-sectional

Authors

ACAram V. ChobanianSumy State A.S.Makarenko Pedagogical University HGHaralambos GavrasGeneral / Preventive / Lipids MBMargaret BresnahanBoston University

Discussion

Member takes

Implication

Supports sympathetic hyperactivity in mild hypertension; hypothesis-generating and should not yet change practice or guide therapy.

Key Points

To evaluate peripheral sympathetic nervous system activity in essential hypertension by measuring plasma catecholamines and norepinephrine under basal and stimulated conditions.
Measured plasma catecholamine and norepinephrine levels under basal conditions and following sympathetic stimulation (70-degree upright tilt and cold pressor testing) in ambulatory hypertensive patients and matched controls.
Assessed sympathetic response to furosemide administration and evaluated plasma norepinephrine variations across plasma renin subgroups and between sexes.
Patients with mild essential hypertension showed higher plasma catecholamine levels compared to matched controls following upright tilt or cold pressor stimulation.
Plasma norepinephrine levels varied markedly across renin subgroups, displaying significantly higher concentrations in high-renin patients and lower concentrations in low-renin patients compared to normal-renin or labile hypertensives.
Blood pressure correlated significantly with plasma norepinephrine in males with normal-renin hypertension but not in females, while furosemide administration produced an increase in plasma norepinephrine across nearly all hypertensive subjects.

Study Design

Type

Observational

Structured PICO

Are plasma catecholamine and norepinephrine concentrations altered in patients with essential hypertension under basal and stimulated conditions?

Population

Ambulatory patients with essential hypertension and matched controls.

Exposure

Experimental procedures to enhance sympathetic activity (70 degree upright tilt, cold pressor testing, and administration of furosemide)

Comparator

Matched controls

Outcome

Plasma catecholamine and norepinephrine concentrationssurrogate

Peripheral sympathetic activity is abnormally elevated in specific subgroups of essential hypertension, particularly those with high plasma renin activity.

Cite This Study

Chobanian et al. (1978) conducted an observational in Essential hypertension. Mild essential hypertension vs. Matched controls was evaluated on Plasma catecholamine and norepinephrine concentrations. Patients with mild essential hypertension demonstrated increased levels of plasma catecholamines compared with matched controls following upright tilt or cold pressor testing.

synapsesocial.com/papers/6aa4c5fe50d1b974a3f2d453 https://doi.org/10.1080/0097840x.1978.9934992

Topics

Hypertension management

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Studies on the Activity of the Sympathetic Nervous System in Essential Hypertension

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Topics

Studies on the Activity of the Sympathetic Nervous System in Essential Hypertension

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider