Why the study?
Does adrenaline infusion reveal differences in platelet noradrenaline and beta-adrenoreceptor responsiveness between hypertensive and normotensive men?
Population
26 healthy white men, including 13 with essential hypertension and 13 normotensives.
Comparison
Adrenaline infusion vs Normotensive control group receiving the same…
Design
Case-control
Authors
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Supports hypothesis of increased sympathetic tone in hypertension; hypothesis-generating and should not yet change practice.
Does adrenaline infusion reveal differences in platelet noradrenaline and beta-adrenoreceptor responsiveness between hypertensive and normotensive men?
Increased platelet noradrenaline and attenuated beta-adrenoreceptor responsiveness in essential hypertension suggest chronically increased sympathetic tone.
Kjeldsen et al. (1994) studied this question.
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