Why the study?
Does exercise and beta adrenoceptor blockade affect left ventricular function differently in hypothyroid patients compared to their euthyroid state?
Population
8 patients with hypothyroidism
Comparison
Exercise and intravenous propranolol before… vs The same patients during thyroxine replacement…
Design
Cohort
Authors
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Supports normal adrenergic sensitivity in hypothyroidism; leaves open beta-blockade dosing implications in clinical practice.
Does exercise and beta adrenoceptor blockade affect left ventricular function differently in hypothyroid patients compared to their euthyroid state?
Left ventricular function is reversibly depressed by thyroid hormone deficiency, but responses to exercise and beta-blockade remain normal, indicating no altered adrenergic sensitivity.
Forfar et al. (1982) studied this question.
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