The V-ATPase Subunit C Binds to Polymeric F-actin as Well as to Monomeric G-actin and Induces Cross-linking of Actin Filaments

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Population

Recombinant V-ATPase subunit C and actin from the midgut of the tobacco hornworm

Design

Preclinical

Authors

Discussion

May link V-ATPase to actin dynamics in cardiovascular cells; leaves open functional roles in contractility or remodeling.

Population

Recombinant V-ATPase subunit C and actin (F-actin and G-actin) from the midgut of the tobacco hornworm (Manduca sexta)

Intervention

Recombinant V-ATPase subunit C

Outcome

Binding affinity to F-actin and G-actin, stabilization of F-actin, rate of actin polymerization, and cross-linking of actin filamentssurrogate

V-ATPase subunit C binds to both monomeric and polymeric actin with high affinity, stabilizing and cross-linking actin filaments.

Vitavska et al. (2004) studied this question.

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