Memory decline accompanies subthreshold amyloid accumulation
Why the study?
Is subthreshold amyloid accumulation associated with longitudinal changes in memory or executive function in cognitively normal older individuals?
Population
142 cognitively normal older individuals enrolled in the Alzheimer's Disease Neuroimaging Initiative who…
Design
Cohort
Follow-up
3.9 ± 1.4 years
Authors
Discussion
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Member takes
Implication
May flag early memory vulnerability in normal cognition; hypothesis-generating for subthreshold amyloid as progression biomarker.
Structured PICO
Is subthreshold amyloid accumulation associated with longitudinal changes in memory or executive function in cognitively normal older individuals?
P
Population
142 cognitively normal older individuals enrolled in the Alzheimer's Disease Neuroimaging Initiative who were Aβ-negative at baseline and who had at least 2 [18F]-florbetapir PET scans
O
Outcome
longitudinal changes in memory or executive functionsurrogate
Subthreshold amyloid accumulation in cognitively normal older adults is associated with memory decline, suggesting it may be an early indicator of pathology.
Cite This Study
Landau et al. (2018) studied this question.