Why the study?
Does renin-angiotensin-aldosterone system blockade delay the progression of chronic nephropathies in patients with chronic proteinuric nephropathy?
Does renin-angiotensin-aldosterone system blockade delay the progression of chronic nephropathies in patients with chronic proteinuric nephropathy?
RAAS blockade with ACE inhibitors or ARBs should be initiated as early as possible and titrated to maximal tolerated doses to delay the progression of chronic proteinuric nephropathies.
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Strengthens case for RAAS blockade in proteinuric CKD; leaves open need for updated RCTs with contemporary comparators.
Tylicki et al. (2005) studied this question.
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