Why the study?
Does spironolactone alone or in combination with cilazapril reduce proteinuria and renal interstitial fibrosis in a rat model of progressive nephritis?
Population
Wistar rats, uninephrectomized 7 days before injection of anti-Thy-1 monoclonal antibody 1-22-3 to induce…
Comparison
Spironolactone, cilazapril, or both for 10 weeks vs Untreated nephritic rats
Design
Preclinical
Follow-up
10 weeks
Authors
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Supports dual therapy rationale in experimental nephritis; leaves open translation to human progressive kidney disease.
Does spironolactone alone or in combination with cilazapril reduce proteinuria and renal interstitial fibrosis in a rat model of progressive nephritis?
Concomitant treatment with spironolactone and an ACE inhibitor ameliorates proteinuria and renal interstitial fibrosis in a rat model of immune-initiated progressive kidney disease.
Asai et al. (2004) studied this question.
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