The Granulocyte Response to an Endotoxin (Pyrexal) as a Measure of Functional Marrow Reserve in Cancer Chemotherapy

Article1 November 1962The Granulocyte Response to an Endotoxin (Pyrexal) as a Measure of Functional Marrow Reserve in Cancer ChemotherapyMARTIN E. FINK, M.D., PAUL CALABRESI, M.D.MARTIN E. FINK, M.D.Search for more papers by this author, PAUL CALABRESI, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-57-5-732 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe large number of myelosuppressive drugs currently used in the treatment of patients with neoplastic disease necessitates more accurate evaluation of bone marrow reserve. This is important because the condition of individual marrow reserves may vary considerably, particularly in patients who have had previous surgery, irradiation, or chemotherapy, and in those who have either depletion of proteins or myelophthisis.The usual criteria for determining drug dosages and intervals between treatments have been primarily peripheral blood studies and, less frequently, bone marrow aspirations. Both techniques have proven inadequate because they do not predict the response of the functional bone marrow reserve...References1. HEILMEYER J: A test of leukopoietic function of the bone marrow. Deutsch. Med. Wschr. 2: 683, 1957. Google Scholar2. CRADDOCKPERRYVENTZKELAWRENCE CGSLEJS: Evaluations of marrow granulocyte reserves in normal and disease states. Blood 15: 840, 1960. CrossrefMedlineGoogle Scholar3. FINKCALABRESI MEP: Functional marrow reserve in patients treated with myelosuppressive agents. Clin. Res. 8: 370, 1960. Google Scholar4. FINK ME: Leukocyte response to endotoxin stimulation in patients treated with 5-fluorouracil. Proc. Amer. Ass. Cancer Res. 3: 224, 1961. Google Scholar5. MECHANICFREITANDY RCEM: Human leukocyte and febrile responses to graduated and repeated doses of a purified bacterial endotoxin. Clin. Res. 9: 163, 1961. Google Scholar6. PERRYWEINSTEINCRADDOCKLAWRENCE SIMCGJS: The combined use of typhoid vaccine and P32 labeling to assess myelopoiesis. Blood 12: 549, 1957. CrossrefMedlineGoogle Scholar7. ATHENSHAABRAABMAUERASHENBRUCKERCARTWRIGHTWINTROBE JWOPSOAMHGEMM: Leukokinetic studies. IV. The total blood, circulation and marginal granulocyte pools and the granulocyte turnover rate in normal subjects. J. Clin. Invest. 40: 989, 1961. CrossrefMedlineGoogle Scholar8. WELLSSOYLEMEZOGLU JAB: Suppression of leukocyte response to bacterial pyrogen by nitrogen mustard. J. Pharmacol. Exp. Ther. 103: 366, 1951. Google Scholar9. WANGWELLS IHJA: Leukocyte response to pyrogen as an indicator of bone marrow depression. Fed. Proc. 12: 378, 1953. Google Scholar10. EICHENBERGERSCHMIDHAUSER-KOPPHURINFRICSAYWESTPHAL EVMHMO: Biological effects of a highly purified bacterial pyrogen from Salmonella abortus equi. Schweiz. Med. Wschr. 85: 1190, 1955. MedlineGoogle Scholar11. SABIN FR: Bone marrow. Physiol. Rev. 8: 191, 1928. CrossrefGoogle Scholar12. DOANZERFAS CALG: The rhythmic range of the white blood cells in human, pathological leukopenic and leukocytic states, with a study of thirty-two human bone marrows. J. Exp. Med. 45: 511, 1927. CrossrefGoogle Scholar13. CURRERI AR: Further clinical studies with 5-fluorouracil. Proc. Amer. Ass. Cancer Res. 3: 14, 1959. Google Scholar14. CURRERIANSFIELDMCIVERWAISMANHEIDELBERGER ARFJGAHGC: Clinical studies with 5-fluorouracil. Cancer Res. 18: 478, 1958. MedlineGoogle Scholar15. ANSFIELDCURRERI FJAR: Further clinical studies with 5-fluorouracil. J. Nat. Cancer Inst. 22: 497, 1959. MedlineGoogle Scholar16. CALABRESIBRODYPERILLIEFINCH PJLPESC: Clinical experience with 5-fluorouracil. Conn. Med. 24: 415, 1960. MedlineGoogle Scholar17. ZUBROD GC: Effects of 5-fluorouracil and 5-fluorodeoxyuridine on gastrointestinal cancer. JAMA 178: 832, 1961. CrossrefGoogle Scholar18. KENNEDYTHEOLOGIDES BJA: The role of 5-fluorouracil in malignant disease. Ann. Intern. Med. 55: 719, 1961. LinkGoogle Scholar19. WEISSJACKSONCARABASI AJLGR: An evaluation of 5-fluorouracil in malignant disease. Ann. Intern. Med. 55: 731, 1961. LinkGoogle Scholar20. OLSONGREENE KBJR: Evaluation of 5-fluorouracil in the treatment of cancer. J. Nat. Cancer Inst. 25: 133, 1960. MedlineGoogle Scholar21. FINKCALABRESI MEP: Unpublished data. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MARTIN E. FINK, M.D.; PAUL CALABRESI, M.D.Affiliations: New Haven, ConnecticutFrom the Departments of Medicine and Pharmacology, Yale University School of Medicine, New Haven, Connecticut.Presented in part at the fifty-second annual meeting of the American Association for Cancer Research, Atlantic City, New Jersey, April 7, 1961.Supported in part by United States Public Health Service Grants CY-5944, H-1577, and OG-14.Dr. Fink is a United States Public Health Service Postdoctoral Fellow, CF-14506.Requests for reprints should be addressed to Martin E. Fink, M.D., Section of Hematology, Yale University School of Medicine, 333 Cedar Street, New Haven 11, Connecticut. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPharmacological Differences, Qualitative and Quantitative, Between Man and Other SpeciesBenign ethnic neutropenia: What is a normal absolute neutrophil count?Superoxide anion (O2-) production and bactericidal capacity of polymorphonuclear neutrophils obtained from patients subjected to glucagon testMarrow neutrophil reserve after adjuvant chemotherapy for carcinoma of the breastKlinik der malignen LymphomeReferencesThe biologic effects of bacterial endotoxin: A short reviewMarrow granulocyte reserves in black AmericansAssessment of myelotoxic effects of chemotherapy from early leukopenic response: Application of a mathematical model for granulopoiesisEffects of acute endotoxemia and glucose administration on circulating leukocyte populations in normal and diabetic subjectsImpaired Marrow Granulocyte Reserve and Leukocyte Mobilization in Leukemic ReticuloendotheliosisLUNG T. YAM, M.D., AFTAB A. CHAUDHRY, M.D., ANTHONY J. JANCKILA, B.S.PREDICTION OF AZATHIOPRINE INTOLERANCE IN TRANSPLANT PATIENTSThe effect of lithium carbonate on the granulocyte phagocytic indexNeutrophil leukocyte reserves in lymphoreticular malignanciesAssessment of the value of prednisone test in differential diagnosis of neutropenic statesStudies on the neutropenia of cancer chemotherapyGranulozytenmobilisation durch Endotoxin bei Mäusen nach Infektion mit Rauscher-VirusThe Etiocholanolone Test for Prediction of the Leukopenic Effect of Cytotoxic DrugsDefective Neutrophil Chemotaxis and Cellular Immunity in a Child with Recurrent InfectionsROBERT A. CLARK, M.D., RICHARD K. ROOT, M.D., HARRY R. KIMBALL, M.D., CHARLES H. KIRKPATRICK, M.D.Cell Proliferation Characteristics and Cancer ChemotherapyLeucocyte Response to Bacterial Endotoxin in Mice Pre-treated with Cytotoxic AgentsAppraisal of MyelopoiesisCurrent cancer chemotherapy in obstetrics and gynecologyTHE USE OF ETIOCHOLANOLONE FOR THE MEASUREMENT OF MARROW GRANULOCYTE RESERVESPrednisolone-Induced GranulocytosisEtiocholanolone in the Evaluation of Marrow Reserves in Patients Receiving Cytotoxic AgentsJAMES M. VOGEL, M.D., HARRY R. KIMBALL, M.D., SHELDON M. WOLFF, M.D., F.A.C.P., SEYMOUR PERRY, M.D., F.A.C.P.The Biological Properties of Etiocholanolone Combined Clinical Staff Conference at the National Institutes of HealthSHELDON M. WOLFF, M.D., F.A.C.P., HARRY R. KIMBALL, M.D., SEYMOUR PERRY, M.D., F.A.C.P., RICHARD ROOT, M.D., ATTALLAH KAPPAS, M.D., F.A.C.P.Response of the rat to intraperitoneal injection of E. coli endotoxinTreatment of cyclic neutropenia with testosteroneHaematological Aspects during Treatment with Anticonvulsant DrugsEndotoxin-induced Neutrophil Response in Miniature Pigs ingesting Strontium-90 Daily 1 November 1962Volume 57, Issue 5Page: 732-742KeywordsBone marrowChemotherapyDrugsEndotoxinsGranulocytesMedical servicesPatientsPharmacologyProteinsSurgery ePublished: 1 December 2008 Issue Published: 1 November 1962 PDF downloadLoading ...