Establishment of predictive nomogram and web-based survival risk calculator for desmoplastic small round cell tumor: A propensity score-adjusted, population-based study

Figures

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  Figure 1.. Study design and the workflow diagram. DSRCT: Desmoplastic small round cell tumor; ROC: Receiver operating characteristic; C-index: Concordance index; SEER: Surveillance, Epidemiology, and End Results; LASSO: Least absolute shrinkage and selection operator.

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  Figure 2.. Correlation analysis and LASSO regression model. The results of correlation analysis between all included variables (A). Selection of tuning parameter (λ) for the LASSO model in OS (B) and CSS (D); LASSO coefficients of 14 features in OS (C) and CSS (E). OS: Overall survival; CSS: Cancer-specific survival; LASSO: Least absolute shrinkage and selection operator.

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  Figure 3.. Forest plot demonstrating the LASSO-Cox regression model for OS (A) and CSS (B) in the training cohort and the nomogram for predicting 1-, 2- and 3-year OS (C) and CSS (D). *Others include ≤ 4 cm and unknown. OS: Overall survival; CSS: Cancer-specific survival; LASSO: Least absolute shrinkage and selection operator.

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  Figure 4.. Time-dependent ROC curves comparing the use of the nomogram and SEER-stage system to predict the 1-, 2- and 3-year OS and CSS in the training cohort (A and C) and the internal validation cohort (B and D). ROC: Receiver operating characteristic; AUC: Area under the curve; OS: Overall survival; CSS: Cancer-specific survival.

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  Figure 5.. Overview of risk-stratification system according to risk points calculated by nomogram. OS and CSS analysis of patients with DSRCT in the training cohort (A and B) and validation cohort (C and D). The distribution of clinicopathological features in different risk groups for OS (E) and CSS (F). OS: Overall survival; CSS: Cancer-specific survival; DSRCT: Desmoplastic small round cell tumor.

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  Figure 6.. Comparison of survival differences between treatment strategies analyzed by PSM. Survival curves of two groups before and after matching analysis in OS (A and C) and CSS (B and D). PSM: Propensity score matching; OS: Overall survival; CSS: Cancer-specific survival; SRC: Triple-therapy (surgery plus radiation and chemotherapy).