Key result
A 67-year-old man with decompensated heart failure was diagnosed with late-stage tuberculous effusive-constrictive pericarditis based on an exceptionally high pericardial fluid ADA level of 952 U/L despite negative cultures.
Case Report (n=1)
This case highlights the diagnostic utility of exceptionally high pericardial fluid Adenosine Deaminase (ADA) levels in confirming tuberculous effusive-constrictive pericarditis when conventional microbiological cultures are negative.
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Case of calcific constrictive pericarditis in COPD patient illustrates diagnostic challenges; leaves open optimal management strategies.
Summary Calcific constrictive pericarditis is an uncommon, yet severe manifestation of chronic pericardial inflammation, leading to diastolic heart failure through lower myocardial compliance secondary to pericardial stiffening. Its etiologies are diverse, including infectious, iatrogenic and autoimmune causes, with tuberculosis remaining a primary offender in endemic regions. We present the case of a 67-year-old male with a history of chronic obstructive pulmonary disease (COPD) and permanent atrial fibrillation, admitted with decompensated global heart failure. Chest radiography revealed extensive, circumferential pericardial calcifications, resembling a plate armour, and a large, calcified saccular collection. Echocardiography confirmed features of constriction, including septal bounce and annulus reversus. Computed tomography further delineated the “armored heart” morphology and a large, compressive, calcified collection over the right ventricle. Diagnostic pericardiocentesis yielded a smooth, “café au lait” coloured fluid. While microbiological analysis for Mycobacterium tuberculosis was negative, the pericardial fluid Adenosine Deaminase (ADA) level was exceptionally high at 952 U/L. The diagnosis of tuberculous effusive-constrictive pericarditis in its late, burnt-out fibrocalcific stage was thus established. This case provides a striking visual correlation between classic clinical signs of constriction and their underlying anatomical pathology, underscoring the diagnostic utility of ADA in culturenegative cases.
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Valentin-Andrei et al. (2025) conducted a case report in Calcific constrictive pericarditis (n=1). Adenosine Deaminase (ADA) testing was evaluated. A 67-year-old man with decompensated heart failure was diagnosed with late-stage tuberculous effusive-constrictive pericarditis based on an exceptionally high pericardial fluid ADA level of 952 U/L despite negative cultures.
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