Why the study?
Does the presence of ventricular midwall fibrosis on LGE-CMR predict mortality and arrhythmic events?
Cohort (n=472)
No
Does the presence of ventricular midwall fibrosis on LGE-CMR predict mortality and arrhythmic events?
Hazard Ratio: 2.96
Absolute Event Rate: 26.8% vs 10.6%
p-value: p=<0.01
The presence of midwall fibrosis on LGE-CMR is a strong predictor of mortality and sudden cardiac death, which could help refine risk stratification for ICD implantation.
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Lepor et al. (2014) conducted a cohort in Nonischemic dilated cardiomyopathy (n=472). Midwall fibrosis (MWF) vs. Absence of midwall fibrosis was evaluated on All-cause mortality (HR 2.96, p=<0.01).
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