Key result
Ambulatory hypertension despite optimal or normal office BP was associated with higher cardiovascular event rates (9.4% and 8.3%) compared to ambulatory normotension (5.6%).
Why the study?
Does optimal or normal office blood pressure rule out ambulatory hypertension and its associated cardiovascular risk in adults without major cardiovascular diseases?
Population
1700 men and women, age 41–72 years, without major cardiovascular diseases.
Comparison
Optimal office BP or normal office BP with… vs Ambulatory normotension (daytime BP < 135/85)
Design
Cohort
Follow-up
mean 9.5 years
Authors
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Office BP alone may miss ambulatory hypertension with higher CV event risk; leaves open whether ABPM-guided therapy improves outcomes.
Cohort (n=1,700)
Does optimal or normal office blood pressure rule out ambulatory hypertension and its associated cardiovascular risk in adults without major cardiovascular diseases?
Absolute Event Rate: 9.4% vs 5.6%
Optimal and normal office blood pressure do not rule out ambulatory hypertension, which is associated with an increased risk of cardiovascular events.
Jeppesen et al. (2005) conducted a cohort in ambulatory hypertension (n=1,700). Ambulatory hypertension with optimal or normal office BP vs. Ambulatory normotension was evaluated on cardiovascular death, ischemic heart disease, or stroke. Ambulatory hypertension despite optimal or normal office BP was associated with higher cardiovascular event rates (9.4% and 8.3%) compared to ambulatory normotension (5.6%).
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