Key result
Non-optimal office BP in young adults is linked to ~7 mmHg higher 24-hour ambulatory BP.
Why the study?
Minimal elevations in blood pressure increase cardiovascular risk from young ages, but mechanisms linking non-optimal BP to risk markers are not defined.
Do apparently healthy young adults with non-optimal office blood pressure have worse cardiometabolic and echocardiographic risk markers compared to those with optimal blood pressure?
Population
135 apparently healthy normotensive undergraduate medical students, mean age 22.5±3.5 years, 76% female
Comparison
Non-optimal office blood pressure vs optimal office blood pressure
Design
Cross-sectional study with blinded statistical analysis
Authors
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Early CV changes seen in youth with BP above optimal; leaves open whether ABPM refines risk stratification beyond office readings.
Cross-Sectional (n=135)
Blinded analysis
No
Do apparently healthy young adults with non-optimal office blood pressure have worse cardiometabolic and echocardiographic risk markers compared to those with optimal blood pressure?
Absolute Event Rate: 117.5% vs 110.4%
p-value: p=<0.001
Apparently healthy young adults with non-optimal office blood pressure exhibit early signs of increased cardiovascular risk, including higher left ventricular mass and worse metabolic markers, compared to those with optimal blood pressure.
Espeche et al. (2024) conducted a cross-sectional in Apparently healthy normotensive young adults (n=135). Non-optimal office blood pressure (≥120/80 but <140/90 mmHg) vs. Optimal office blood pressure (<120/80 mmHg) was evaluated on 24-hour systolic blood pressure on ambulatory monitoring (p=<0.001). Apparently healthy young adults with non-optimal office blood pressure exhibited significantly higher 24-hour ambulatory blood pressure, left ventricular mass index, and markers of insulin resistance compared to those with optimal blood pressure.
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