Key result
Higher visceral adiposity index and lipid accumulation product were independently associated with an increased risk of intracranial atherosclerotic stenosis in middle-aged and elderly Chinese females (VAI OR 3.25).
Why the study?
Do higher visceral adiposity index and lipid accumulation product correlate with increased risk of intracranial atherosclerotic stenosis in middle-aged and elderly Chinese patients?
Cross-Sectional (n=845)
No
Do higher visceral adiposity index and lipid accumulation product correlate with increased risk of intracranial atherosclerotic stenosis in middle-aged and elderly Chinese patients?
Odds Ratio: 3.25 (95% CI 1.17–9.03)
p-value: p=0.024
VAI and LAP are independently associated with an increased risk of intracranial atherosclerotic stenosis in middle-aged and elderly Chinese females, suggesting their utility as sex-specific surrogate markers for cerebrovascular risk.
Suggests these indices may serve as sex-specific surrogate markers for cerebrovascular risk; leaves open.
We investigated the association of the newly established lipid accumulation product (LAP) and visceral adiposity index (VAI) with intracranial atherosclerotic stenosis (ICAS) in middle-aged and elderly Chinese. From June 2012 to January 2013, consecutive patients ≥40 years of age who underwent cerebral vascular imaging for various medical reasons were enrolled in this study. Multivariate logistic regression models were used to evaluate the correlation of VAI and LAP with the risk of ICAS. In total, 845 patients were included in the study. The prevalence of ICAS gradually increased in females and in all patients with advancing tertiles of VAI or LAP. After adjusting for potential risks, both the VAI and LAP were related to ICAS in females [VAI: odds ratio (OR) = 3.25, 95% confidence interval (95%CI) = 1.17-9.03, P = 0.024; LAP: OR = 4.11, 95%CI = 1.39-12.12, P = 0.011; tertiles 3 vs. 1]. The sensitivity, specificity, and positive predictive value (PPV) were 74.7%, 45.5%, and 84.4% for VAI (cut-off: 1.71) and 79.3%, 40.5%, and 84.1% for LAP (cut-off: 23.99). The same relationships in males were not significant. Both VAI and LAP were closely associated with an increased risk of ICAS in middle-aged and elderly Chinese females.
No takes yet. Share an insight, caveat, or question.
Li et al. (2017) conducted a cross-sectional in Intracranial atherosclerotic stenosis (ICAS) (n=845). Visceral adiposity index (VAI) vs. Lowest VAI tertile was evaluated on Risk of intracranial atherosclerotic stenosis (ICAS) in females (highest vs lowest tertile) (OR 3.25, 95% CI 1.17-9.03, p=0.024). Higher visceral adiposity index and lipid accumulation product were independently associated with an increased risk of intracranial atherosclerotic stenosis in middle-aged and elderly Chinese females (VAI OR 3.25).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: