What does this research mean for the field?

The catestatin Gly364Ser variant exhibits significantly diminished anti-hypertensive and cardioprotective efficacy compared to wild-type catestatin in a hypertensive animal model. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

What question did this study set out to answer?

To determine the differential anti-hypertensive, cardioprotective, and anti-inflammatory effects of wild-type catestatin versus its common human Gly364Ser variant in a rat model of hypertension.

November 25, 2024Bioscience ReportsOpen Access

The physiological anti-hypertensive peptide catestatin and its common human variant Gly364Ser: differential cardiovascular effects in a rat model of hypertension

Q: What are the key findings of this study?

The CST-Ser variant was profoundly less effective than CST-WT in reducing systolic blood pressure (~176 mmHg vs ~116 mmHg) and heart rate in a rat model of hypertension.

Q: What is the clinical evidence from this study?

Study design: Other. Population: Hypertension. Intervention: Catestatin 364Ser variant (CST-Ser) vs. Catestatin wild-type (CST-WT). Primary outcome: Systolic blood pressure.

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Key result

Catestatin variant CST-Ser blunts BP reduction vs. wild-type, leaving systolic BP ~60 mmHg higher.

Why the study?

Does the CST-Gly364Ser variant have diminished anti-hypertensive and cardioprotective effects compared to wild-type catestatin in a rat model of hypertension?

Population

Uninephrectomized rats with hypertension induced by deoxycorticosterone-acetate and sodium chloride

Comparison

Intraperitoneal administration of catestatin… vs Intraperitoneal administration of catestatin…

Design

Preclinical

Authors

JRJitesh S. RatheeBhabha Atomic Research Centre DIDhanya R. IyerIndian Institute of Technology Madras MKMalapaka KiranmayiIndian Institute of Technology Madras

Discussion

Member takes

Implication

The common human variant of catestatin (Gly364Ser) exhibits diminished anti-hypertensive and cardioprotective effects compared to the wild-type peptide in a hypertensive rat model, providing a mechanistic basis for elevated blood pressure observed in human carriers.

Key Points

To determine the differential anti-hypertensive, cardioprotective, and anti-inflammatory effects of wild-type catestatin versus its common human Gly364Ser variant in a rat model of hypertension.
Induced hypertension in uninephrectomized rats using deoxycorticosterone-acetate and sodium chloride (DOCA-salt).
Administered intraperitoneal injections of either wild-type catestatin (CST-WT) or the Gly364Ser variant (CST-Ser) to hypertensive rats.
Measured hemodynamics, cardiac contractility, end-diastolic pressure, and myocardial inflammation following peptide administration.
CST-Ser was significantly less effective than CST-WT in lowering systolic blood pressure (from ~211 to ~176 mmHg, p < 0.0001 vs ~116 mmHg, p < 0.0001) and heart rate (from ~356 to ~314 bpm, p = 0.66 vs ~276 bpm, p = 0.02).
CST-Ser showed blunted recovery of cardiac function, improving the contractility index by ~22 s⁻¹ (p = 0.15) versus ~84 s⁻¹ (p < 0.0001) and reducing end-diastolic pressure by ~4 mmHg (p = 0.015) versus ~14 mmHg (p < 0.0001) for CST-WT.
CST-Ser displayed diminished efficacy in reducing diastolic blood pressure, mean arterial pressure, and cardiac inflammation compared to CST-WT.

Structured PICO

Does the CST-Gly364Ser variant have diminished anti-hypertensive and cardioprotective effects compared to wild-type catestatin in a rat model of hypertension?

Population

DOCA-salt-induced hypertensive uninephrectomized rats.

Intervention

Intraperitoneal administration of catestatin 364Ser variant (CST-Ser)

Comparator

Intraperitoneal administration of catestatin wild-type (CST-WT)

Outcome

Systolic blood pressure and heart ratesurrogate

Main Result

Absolute Event Rate: 176% vs 116%

Cite This Study

Rathee et al. (2024) studied Hypertension. Catestatin 364Ser variant (CST-Ser) vs. Catestatin wild-type (CST-WT) was evaluated on Systolic blood pressure. The CST-Ser variant was profoundly less effective than CST-WT in reducing systolic blood pressure (~176 mmHg vs ~116 mmHg) and heart rate in a rat model of hypertension.

synapsesocial.com/papers/6a8968d11fb56efa37d44b85 https://doi.org/10.1042/bsr20241433

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The physiological anti-hypertensive peptide catestatin and its common human variant Gly364Ser: differential cardiovascular effects in a rat model of hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

The physiological anti-hypertensive peptide catestatin and its common human variant Gly364Ser: differential cardiovascular effects in a rat model of hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

Also Consider

Also Consider