Key result
Blood pressure reduction in early-stage hypertension over 6 years improved large artery compliance (C1 increased by 2.0 ml/mmHgx10; 95% CI 1.1-4.4; P<0.001).
Why the study?
Does blood pressure reduction with non-pharmacological or pharmacological therapy improve arterial distensibility in young-to-middle-age stage 1 hypertensive subjects?
Cohort (n=192)
Does blood pressure reduction with non-pharmacological or pharmacological therapy improve arterial distensibility in young-to-middle-age stage 1 hypertensive subjects?
Mean Difference: 2 (95% CI 1.1–4.4)
p-value: p=<0.001
Blood pressure reduction in early-stage hypertension improves large artery compliance over the long term, though elevated heart rate may counteract these benefits.
No takes yet. Share an insight, caveat, or question.
May support early BP control for vascular benefits in stage 1 hypertension; hypothesis-generating and should not yet change practice.
Saladini et al. (2010) conducted a cohort in Stage 1 hypertension (n=192). Blood pressure reduction vs. Baseline was evaluated on Change in large artery compliance (C1) (MD 2.0 ml/mmHgx10, 95% CI 1.1-4.4, p=<0.001). Blood pressure reduction in early-stage hypertension over 6 years improved large artery compliance (C1 increased by 2.0 ml/mmHgx10; 95% CI 1.1-4.4; P<0.001).
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