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July 1, 2026Dose-ResponseOpen Access

Prediction of the Dose and Dose-Rate of Ionizing Radiation that Provides the Greatest Biological Benefit

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Authors

KKKatsuhito Kino

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Overview

Theoretical modeling reveals biological benefits of radiation at dose-rates below 1 mGy/h, suggesting optimal protective ranges at cumulative doses above 350 mGy.

Key Points

  • To identify the specific radiation doses and dose-rates that maximize biological benefits by incorporating dose-rate dependency into the hormesis-coupled linear no-threshold theory.
  • Applied the previously formulated hormesis-coupled linear no-threshold (LNT) theoretical model across varying radiation dose-rates.
  • Calibrated model parameters using published empirical radiation response data (Yoshida et al. 2008).
  • Calculated that biological benefit from ionizing radiation is observable at dose-rates below 1 mGy/h.
  • Identified that potentially beneficial biological factors occur within a cumulative exposure region exceeding 350 mGy at these low dose-rates.

Cite This Study

Katsuhito Kino (2026) studied this question.

synapsesocial.com/papers/6a89691b186271ac99333cb7https://doi.org/10.1177/15593258261477574
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Also Consider

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  1. 1Questioning the Linear No-Threshold Model (LNT): Lessons From Hiroshima/Nagasaki and Fukushima2025
  2. 2Calculations of the Radiation Dose for the Maximum Hormesis Effect2024
  3. 3A study of threshold-like behavior in low-dose radiation risk using improved statistical evaluation methods and implications for further investigation2026
  4. 4A Critical Assessment of the Linear No-Threshold Hypothesis2019 · 25 citations
  5. 5Dose-Dependent Dual Effects of Gradient Ionizing Radiation on Neurocognition2026