Key result
In two independent cohorts of ESRD patients, circulating PTX3 levels were negatively associated with surrogates of adipose tissue, such as fat body mass index, contrasting with the positive associations seen for CRP and IL-6.
Population
372 ESRD patients from Sweden.
Design
Cross-sectional
Authors
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Inverse PTX3-adipose association in ESRD should not change practice; hypothesis-generating for PTX3 as distinct marker versus CRP/IL-6.
Cross-Sectional (n=372)
Yes
Effect estimate: Coefficient -1.08 (95% CI -1.68 to -0.48)
p-value: p=<0.0001
In ESRD patients, PTX3 levels are inversely associated with surrogates of adipose tissue, contrasting with the positive associations seen with CRP and IL-6.
Miyamoto et al. (2011) conducted a cross-sectional in End-Stage Renal Disease (n=372). Pentraxin-3 (PTX3) was evaluated on Association between PTX3 (per doubling ng/ml) and fat body mass index (FBMI) in prevalent hemodialysis patients (Coefficient -1.08, 95% CI -1.68 to -0.48, p=<0.0001). In two independent cohorts of ESRD patients, circulating PTX3 levels were negatively associated with surrogates of adipose tissue, such as fat body mass index, contrasting with the positive associations seen for CRP and IL-6.
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