Key result
Bariatric surgery induced early beneficial effects on glucose metabolism and weight loss, but also a tardive, weight-independent increase in hepatic cholesterol metabolism associated with potentially detrimental inflammatory and metabolic effects.
Why the study?
Although bariatric surgery effectively treats severe obesity and related comorbidities, an integrative analysis of the complex body response to surgery is still lacking.
Does bariatric surgery improve clinical, oxidative stress, and metabolic blood biomarkers in patients with severe obesity?
Observational (n=36)
No
Does bariatric surgery improve clinical, oxidative stress, and metabolic blood biomarkers in patients with severe obesity?
While bariatric surgery provides early benefits in weight loss and glucose metabolism, it may also induce a late, weight-independent increase in hepatic cholesterol metabolism and oxidative stress, highlighting potential disregarded health risks.
Potential late hepatic risks warrant monitoring post-bariatric surgery; leaves open net long-term benefit in Level 4 data.
Bariatric surgery (BS) is an effective intervention for severe obesity and associated comorbidities. Although several studies have addressed the clinical and metabolic effects of BS, an integrative analysis of the complex body response to surgery is still lacking. We conducted a longitudinal data study with 36 patients with severe obesity who were tested before, 6 and 12 months after restrictive BS for more than one hundred blood biomarkers, including clinical, oxidative stress and metabolic markers, peptide mediators and red blood cell membrane lipids. By using a synthetic data-driven modeling based on principal component and correlation analyses, we provided evidence that, besides the early, well-known glucose metabolism- and weight loss-associated beneficial effects of BS, a tardive, weight-independent increase of the hepatic cholesterol metabolism occurs that is associated with potentially detrimental inflammatory and metabolic effects. Canonical correlation analysis indicated that oxidative stress is the most predictive feature of the BS-induced changes of both glucose and lipids metabolism. Our results show the power of multi-level correlation analysis to uncover the network of biological pathways affected by BS. This approach highlighted potential health risks of restrictive BS that are disregarded with the current practice to use weight loss as surrogate of BS success.
No takes yet. Share an insight, caveat, or question.
Palleschi et al. (2022) conducted an observational in Severe obesity (n=36). Bariatric surgery vs. Baseline (pre-surgery) was evaluated on Changes in multi-marker biological networks (clinical, oxidative stress, metabolic, peptide mediators, RBC membrane lipids). Bariatric surgery induced early beneficial effects on glucose metabolism and weight loss, but also a tardive, weight-independent increase in hepatic cholesterol metabolism associated with potentially detrimental inflammatory and metabolic effects.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: