Key result
Activated CGRP receptors induce cyclic nucleotide-independent relaxation of vascular smooth muscle cells and terminate arterial effects of ET-1 via G-protein βγ subunits.
Why the study?
Does G-protein βγ subunit inhibition alter the vasorelaxing and anti-endothelinergic effects of CGRP in vascular smooth muscle cells?
Population
Rat isolated mesenteric resistance arteries, membranes from CHO cells expressing human CGRP receptors, and…
Comparison
CGRP receptor stimulation in the presence of… vs Negative control or absence of inhibitors
Design
Preclinical
Authors
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May guide mechanistic studies of CGRP-ET-1 interactions; leaves open clinical translation from animal vessels.
Does G-protein βγ subunit inhibition alter the vasorelaxing and anti-endothelinergic effects of CGRP in vascular smooth muscle cells?
CGRP induces cyclic nucleotide-independent relaxation of vascular smooth muscle cells and terminates the arterial effects of ET-1 via G-protein βγ subunits.
Mattheij et al. (2011) studied this question. Gallein and M119 (Gβγ inhibitors) vs. Control was evaluated on Relaxing and anti-endothelinergic effects of CGRP. Activated CGRP receptors induce cyclic nucleotide-independent relaxation of vascular smooth muscle cells and terminate arterial effects of ET-1 via G-protein βγ subunits.
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