Key result
Endothelin-1 increases afferent renal nerve activity via ETB activation, which is mediated by TRPV1 channels possibly via the protein kinase C pathway.
Population
Wild-type (WT) and TRPV1-null mutant mice
Comparison
Perfusion of Endothelin 1 alone or with various… vs Wild-type vs TRPV1-null mutant mice
Design
Preclinical
Authors
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Hypothesis-generating for ETB-TRPV1 renal nerve signaling in hypertension models; leaves open human translation and clinical relevance.
TRPV1 channels mediate ETB-dependent increases in afferent renal nerve activity, suggesting a mechanism for renal regulation of blood pressure via the protein kinase C pathway.
Xie et al. (2009) studied this question. Endothelin 1 (ET-1) and receptor agonists/antagonists vs. Wild-type vs TRPV1-null mutant mice was evaluated on Afferent renal nerve activity (ARNA) and substance P release. Endothelin-1 increases afferent renal nerve activity via ETB activation, which is mediated by TRPV1 channels possibly via the protein kinase C pathway.
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