Population
Transgenic mice overexpressing renin and angiotensinogen (R+A+ mice) and littermate control mice
Comparison
Ganglionic blockade followed by additional… vs Littermate control mice undergoing the same…
Design
Preclinical
Authors
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May support ganglionic AT1 targeting in renin-angiotensin models; leaves open human translation.
Direct ganglionic action of Angiotensin II significantly contributes to sympathetic nerve activity in mice overexpressing renin and angiotensinogen, driven by increased Ang II levels and AT1 receptor upregulation.
Ma et al. (2003) studied this question.
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