Key result
Administration of a high-fat and high-cholesterol diet combined with L-NAME for 8 weeks accelerated atherosclerosis and induced hypertension and cardiac hypertrophy in Microminipigs.
Absolute Event Rate: 186% vs 135%
p-value: p=<0.05
A Microminipig model fed a high-fat/high-cholesterol diet and administered l-NAME successfully mimics features of metabolic syndrome, including atherosclerosis and cardiac hypertrophy, providing a novel noninvasive preclinical model.
Supports a novel porcine metabolic syndrome model; leaves open translation to human cardiovascular research.
Metabolic syndrome (MetS) induces serious complications; therefore, we developed a noninvasive MetS model using an extremely small minipig, the Microminipig. For 8 weeks, Microminipigs were administrated a high-fat and high-cholesterol diet (HFCD) for atherosclerosis and N(G)-nitro-l-arginine methyl ester (l-NAME) for inhibiting nitric oxide synthase. HFCD significantly increased serum low-density lipoprotein levels, l-NAME increased blood pressure and cardiac hypertrophy, and HFCD-induced aortal arteriosclerosis was accelerated by l-NAME administration. Endothelium-dependent relaxation of the coronary artery was remarkably decreased by l-NAME administration. This model may be useful for elucidating the mechanisms of MetS and developing new therapeutic medicines for its treatment.
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Yamaguchi et al. (2014) studied Metabolic Syndrome (n=11). High-fat and high-cholesterol diet (HFCD) and L-NAME vs. Normal diet without L-NAME was evaluated on Systolic blood pressure (p=<0.05). Administration of a high-fat and high-cholesterol diet combined with L-NAME for 8 weeks accelerated atherosclerosis and induced hypertension and cardiac hypertrophy in Microminipigs.
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