Identification of 15 novel risk loci for coronary artery disease and genetic risk of recurrent events, atrial fibrillation and heart failure
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Key result
A meta-analysis of genetic data identified 15 novel genome-wide significant loci associated with coronary artery disease, expanding known risk loci by 20% and highlighting genes involved in angiogenesis.
Why the study?
Do specific genetic variants increase the risk of coronary artery disease and other cardiovascular phenotypes in the general population?
Population
278,915 individuals from UK Biobank and CARDIoGRAMplusC4D. UK Biobank CAD cases mean age 61.5 years…
Comparison
Genetic variants associated with CAD vs Reference alleles / non-carriers
Design
Meta-analysis
Authors
Discussion
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Implication
Highlights angiogenesis as a potential therapeutic target for CAD; extends the known genetic architecture while leaving open the.
Study Design
Type
Meta-Analysis (n=278,915)
Multicenter
Yes
Structured PICO
Do specific genetic variants increase the risk of coronary artery disease and other cardiovascular phenotypes in the general population?
P
Population
278,915 individuals from the UK Biobank and CARDIoGRAMplusC4D cohorts, aged 40-69 years, analyzed to identify novel genetic risk loci for coronary artery disease.
E
Exposure
Genetic variants associated with CAD (161 independent variants passing P < 10^-5 in CARDIoGRAMplusC4D)
C
Comparator
Reference alleles / non-carriers
O
Outcome
Coronary artery disease (CAD) statushard clinical
Main Result
p-value: p=< 5 × 10^-8
The identification of 15 novel genetic loci for CAD expands the understanding of its genetic basis and highlights pathways like angiogenesis as potential therapeutic targets.
Limitations
- The associative nature of the analyses requires further functional experiments to establish true causal genes and mechanisms.
- The strategy did not reveal coronary artery disease variants of low frequency (minor allele frequency < 0.05-1%).
- Did not reveal CAD variants of low frequency (MAF < 1-0.05%)
Cite This Study
Verweij et al. (2017) conducted a meta-analysis in Coronary artery disease (n=278,915). Genetic risk loci vs. Non-carriers / reference alleles was evaluated on Genome-wide significant association with coronary artery disease (p=< 5 × 10^-8). A meta-analysis of genetic data identified 15 novel genome-wide significant loci associated with coronary artery disease, expanding known risk loci by 20% and highlighting genes involved in angiogenesis.
Topics
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