Key result
In patients with preexisting carotid disease, the annual rate of increase in vessel-wall volume was significantly slower in those receiving statin therapy compared with those not receiving statin therapy (1.14% vs 7.87%).
Why the study?
Does statin therapy reduce the progression of carotid artery vessel-wall volume in patients with >50% narrowing?
Population
160 patients with greater than 50% narrowing of the diameter of the carotid artery, recruited at six U.S…
Comparison
Statin therapy vs No statin therapy
Design
Cohort
Follow-up
1 year
Authors
Loading...
Supports slower carotid plaque progression with statins on MRI; leaves open randomized confirmation before practice change.
Observational (n=160)
Blinded assessors
Yes
Does statin therapy reduce the progression of carotid artery vessel-wall volume in patients with >50% narrowing?
Absolute Event Rate: 1.14% vs 7.87%
p-value: p=0.029
Quantitative evaluation of carotid plaque progression is feasible with 1.5-T MRI, which successfully detected a slower rate of vessel-wall volume increase in patients on statin therapy.
Boussel et al. (2009) conducted an observational in Atherosclerotic plaque progression in carotid arteries (n=160). Statin therapy vs. No statin therapy was evaluated on Annualized rate of progression of vessel-wall volume (p=0.029). In patients with preexisting carotid disease, the annual rate of increase in vessel-wall volume was significantly slower in those receiving statin therapy compared with those not receiving statin therapy (1.14% vs 7.87%).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: