Key result
High-fat diet increased basal heart rate (~10%) and evoked metabolic disruptions independently of chronic variable stress, which increased cardiac sympathetic activity (~65%).
Why the study?
Does the combination of high-fat diet and chronic variable stress exacerbate cardiovascular and metabolic disturbances in rats compared to either factor alone?
Population
Male Wistar rats (n=32)
Comparison
High-fat diet combined with chronic variable… vs Standard chow diet without stress, HFD without…
Design
Preclinical
Follow-up
4 weeks
Authors
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High-fat diet and chronic stress independently affect rat cardiac parameters; leaves open synergistic cardiometabolic effects in humans.
Does the combination of high-fat diet and chronic variable stress exacerbate cardiovascular and metabolic disturbances in rats compared to either factor alone?
In a rat model, high-fat diet and chronic variable stress independently induce cardiovascular and metabolic disturbances without synergistic interaction on autonomic imbalance.
Simas et al. (2018) studied Cardiovascular and metabolic disturbances (n=32). High-fat diet (HFD) and chronic variable stress (CVS) vs. Standard chow diet (SD) and no stress was evaluated on Cardiovascular function, autonomic activity, dietary intake, adiposity and metabolism. High-fat diet increased basal heart rate (~10%) and evoked metabolic disruptions independently of chronic variable stress, which increased cardiac sympathetic activity (~65%).
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